38.10%
mean improvement in dark-circle appearance
Week 6
Expert grading, n=33; p<0.001.
SeneGenceReview6-Week Independent Eye-Area Study
NeoTight™ Eye Serum
Brighter-looking eyes, with visible results that deepen over time.
Expert grading documented significant Week 6 improvements in the appearance of dark circles, puffiness, and peri-orbital lines.
33 completed6 weeksExpert graded
23.12%
mean improvement in puffiness or bags
Week 6
Expert grading, n=33; p<0.001.
100%
said the delicate eye area felt nourished
Week 6
Participant perception, n=33.
SeneGenceReviewClinical Results
Results that build
Visible improvement progressed through Week 6.
Dark circles / discoloration38.10%
Expert-graded mean improvement; n=33; p<0.001.
Puffiness / bags23.12%
Expert-graded mean improvement; n=33; p<0.001.
Peri-orbital fine lines8.82%
Expert-graded mean improvement; n=31; p<0.001.
Immediate performance
Fifteen minutes after the first application, Cutometer readings showed an 8.31% improvement in R0 firmness (n=27; p=0.039) and a 15.16% improvement in R5 elasticity (n=27; p=0.001). These immediate instrument findings are presented separately from the Week 4 and Week 6 expert-graded appearance results.
Selected Week 6 participant perceptions
93.94%reported increased smoothness.
93.94%agreed the lightweight texture absorbed quickly, leaving skin soothed and refreshed.
84.85%saw brighter-looking dark circles.
84.85%saw improved bags and puffiness.
75.76%saw improved-looking fine lines.
78.79%saw improved eyelid crepiness.
SeneGenceReviewClinical Results
Technical study record
A signed final source reports the six-week expert-graded eye-area endpoints.
Independent laboratoryValidated Claim Support, LLC
Tested productNeoTight Eye Serum
Design6-week single-arm study with 7-day washout
Population37 enrolled; 33 completed; ages 36-69
UseTwice daily around the eye area
EvidenceExpert grading, Cutometer, photography, questionnaire
Source date8 April 2021
Expert-graded mean change from baseline
| Expert endpoint | 15 minutes | Week 4 | Week 6 |
|---|---|---|---|
| Dark circles / discoloration | -10.20%; n=33; p<0.001 | -31.95%; n=32; p<0.001 | -38.10%; n=33; p<0.001 |
| Puffiness / bags | -8.67%; n=33; p<0.001 | -16.55%; n=32; p<0.001 | -23.12%; n=33; p<0.001 |
| Peri-orbital fine lines | -1.18%; n=31; p=0.161 | -4.57%; n=30; p=0.001 | -8.82%; n=31; p<0.001 |
Lower grades indicate improvement. n is shown for every endpoint and timepoint.
Instrumental timing context
| Cutometer parameter | 15 minutes | Week 4 | Week 6 |
|---|---|---|---|
| R0 firmness | -8.31%; p=0.039 | +32.00%; p<0.001 | +35.17%; p<0.001 |
| R5 elasticity | +15.16%; p=0.001 | -15.74%; p<0.001 | -12.04%; p=0.005 |
R0 decrease and R5 increase indicate improvement. The favorable Cutometer response was recorded at 15 minutes; Week 4 and Week 6 values are included for complete timing context.
Study context
Thirty-three participants completed the study. Two mild adverse events were recorded and no participant withdrew. Results apply to NeoTight Eye Serum under the reported six-week design.
SeneGenceReviewTechnical Evidence
Independent laboratory evidence
Original source pages follow.
View the complete source record.
Selected original VCS pages follow, preserving the study summary, methods, complete aggregate questionnaires, conclusion, authorization, and Quality Assurance evidence. Expert-grade and Cutometer results are reproduced in aggregate on the preceding technical page; participant-level listings are excluded.
The complete PDF pairs this consumer summary with the selected independent laboratory source pages.
Open full PDF + laboratory sourceLaboratoryValidated Claim Support, LLC
Source date8 April 2021
AuthenticationDated electronic authorizations + QA/QC
Source authentication
The source contains dated authorization from Principal Investigator Anna Hardy, review by Medical Investigator David A. Wrone, M.D., and independent QA/QC certification dated 9 April 2021.
Source note
Participant identifiers and participant-level measurement rows were removed from the appended result pages; aggregate mean, p-value, and t-value results are unchanged. Week 4 expert endpoint n=30 is used in the summary.
Independent laboratory source pages are included in the complete PDF. Participant-identifying information has been removed where indicated; aggregate findings are unchanged.
Accessible source-page companion
PDF pages 19–22 are image facsimiles. This companion follows their page order and presents manually checked aggregate tables with the reported sample sizes, timepoints, signs, decimals, p-values, t-values, and direction-of-improvement notes.
Administrative report identifiers and participant-level rows are omitted here. The unchanged signed source PDF remains available above.
PDF page 19 — Expert grading: dark circles and under-eye puffiness
Source date: April 8, 2021. Source page: 17 of 31.
| Grade and scale description | Baseline | Immediate | Week 4 (N=32) | Week 6 |
|---|---|---|---|---|
| 0.0 — No color difference from surrounding skin | 0.00% | 0.00% | 6.25% | 6.06% |
| 0.5 | 0.00% | 3.03% | 6.25% | 15.15% |
| 1.0 — Mild, faint color difference, weak intensity (light brown) | 9.09% | 21.21% | 28.13% | 30.30% |
| 1.5 | 18.18% | 12.12% | 21.88% | 12.12% |
| 2.0 — Moderate color difference and intensity (light brown/tan) | 24.24% | 24.24% | 25.00% | 27.27% |
| 2.5 | 24.24% | 21.21% | 6.25% | 3.03% |
| 3.0 — Moderate/deep color difference (brown/tan) | 18.18% | 15.15% | 3.13% | 3.03% |
| 3.5 | 3.03% | 0.00% | 0.00% | 3.03% |
| 4.0 — Intense/deep color difference (dark brown/tan) | 3.03% | 3.03% | 3.13% | 0.00% |
| Mean score | 2.2 | 2.0 | 1.5 | 1.4 |
| Mean % change | — | -10.20% | -31.95% | -38.10% |
| p | — | 0.000* | 0.000* | 0.000* |
| t | — | 5.164 | 8.824 | 10.619 |
| Grade and scale description | Baseline | Immediate | Week 4 (N=32) | Week 6 |
|---|---|---|---|---|
| 0.0 — None, smooth appearance under eye | 0.00% | 0.00% | 0.00% | 0.00% |
| 0.5 | 0.00% | 0.00% | 0.00% | 6.06% |
| 1.0 — Mild | 3.03% | 3.03% | 12.50% | 6.06% |
| 1.5 | 9.09% | 9.09% | 12.50% | 18.18% |
| 2.0 — Moderate | 18.18% | 39.39% | 34.38% | 36.36% |
| 2.5 | 24.24% | 18.18% | 12.50% | 18.18% |
| 3.0 — Moderate/severe | 27.27% | 21.21% | 21.88% | 12.12% |
| 3.5 | 12.12% | 3.03% | 6.25% | 3.03% |
| 4.0 — Severe, pronounced bags, puffy appearance | 6.06% | 6.06% | 0.00% | 0.00% |
| Mean score | 2.6 | 2.4 | 2.2 | 2.0 |
| Mean % change | — | -8.67% | -16.55% | -23.12% |
| p | — | 0.000* | 0.000* | 0.000* |
| t | — | 4.629 | 6.535 | 8.916 |
Decrease = improvement. * Statistically significant (p<0.050). Week 4 N=32 because one participant missed the visit.
PDF page 20 — Expert grading: peri-orbital fine lines and wrinkles
Source date: April 8, 2021. Source page: 18 of 31.
| Grade and scale description | Baseline | Immediate | Week 4 (N=32) | Week 6 |
|---|---|---|---|---|
| 0.0 — Absence of fine lines | 0.00% | 0.00% | 0.00% | 0.00% |
| 0.5 | 0.00% | 0.00% | 0.00% | 0.00% |
| 1.0 — Slightly visible fine lines | 0.00% | 0.00% | 0.00% | 0.00% |
| 1.5 | 0.00% | 3.23% | 16.67% | 29.03% |
| 2.0 — Clearly visible fine lines and/or wrinkles | 32.26% | 32.26% | 26.67% | 16.13% |
| 2.5 | 25.81% | 22.58% | 13.33% | 12.90% |
| 3.0 — Prominent wrinkles | 16.13% | 16.13% | 16.67% | 19.35% |
| 3.5 | 12.90% | 12.90% | 13.33% | 12.90% |
| 4.0 — Deep, severe lines and wrinkles | 12.90% | 12.90% | 13.33% | 9.68% |
| Mean score | 2.7 | 2.7 | 2.6 | 2.5 |
| Mean % change | — | -1.18% | -4.57% | -8.82% |
| p | — | 0.161 | 0.001* | 0.000* |
| t | — | 1.438 | 3.513 | 5.303 |
Decrease = improvement. * Statistically significant (p<0.050). The source prints Week 4 N=32 because one participant missed the visit; the parameter heading states N=31.
PDF page 21 — Cutometer R0 skin firmness aggregate
Source date: April 8, 2021. Source page: 19 of 31.
This companion presents the aggregate mean, p, and t rows; participant-level rows are omitted.
| Statistic | Baseline | Immediate (N=27) | Immediate % change | Week 4 | Week 4 % change | Week 6 | Week 6 % change |
|---|---|---|---|---|---|---|---|
| Mean | 0.2872 | 0.2633 | -8.31% | 0.3791 | 32.00% | 0.3882 | 35.17% |
| p | — | 0.039* | 0.000* | 0.000* | |||
| t | — | 2.174 | 6.356 | 7.843 | |||
Decrease = improvement. * Statistically significant (p<0.050). Immediate N=27 due to instrument malfunction.
PDF page 22 — Cutometer R5 skin elasticity aggregate
Source date: April 8, 2021. Source page: 20 of 31.
This companion presents the aggregate mean, p, and t rows; participant-level rows are omitted.
| Statistic | Baseline | Immediate (N=27) | Immediate % change | Week 4 | Week 4 % change | Week 6 | Week 6 % change |
|---|---|---|---|---|---|---|---|
| Mean | 0.4620 | 0.5320 | 15.16% | 0.3893 | -15.74% | 0.4064 | -12.04% |
| p | — | 0.001* | 0.000* | 0.005* | |||
| t | — | 3.931 | 4.531 | 3.052 | |||
Increase = improvement. * Statistically significant (p<0.050). Immediate N=27 due to instrument malfunction.