clinical finding
in the study
Ingredient study of Xylitylglucoside, Anhydroxylitol, and Xylitol
what it showed
In the hand study, hydration measured 13.5% higher than the initial measurement at 24 hours; in separate cell assays, hyaluronic-acid production increased 24% in keratinocytes at 0.01% complex and 20% in fibroblasts at 0.1% complex.
A 1.5% Xylitylglucoside, Anhydroxylitol, and Xylitol complex in a 72% v/v alcohol hand gel produced the 24-hour hydration finding, while separate 0.01% keratinocyte and 0.1% fibroblast assays produced the hyaluronic-acid findings.
The hand study and cell assays ask different questions, but both help explain why this sugar complex is used when immediate and lasting hydration is the formula job.
13.5% higher hydration
After 20 volunteers used a hand gel containing 1.5% Xylitylglucoside, Anhydroxylitol, and Xylitol in 72% v/v alcohol at least five times daily, corneometry measured hydration 13.5% higher at 24 hours than the initial measurement.
24% in keratinocytes; 20% in fibroblasts
In separate cell assays, Xylitylglucoside, Anhydroxylitol, and Xylitol increased hyaluronic-acid production by 24% in keratinocytes at 0.01% complex and by 20% in fibroblasts at 0.1% complex; the source does not state the assay duration.