The SeneGence Review

governed appendix · verified 2026-07-10

Every registered current clinical claim. Kept in scope.

This appendix gathers all 47 registered claims for current finished products and named regimens in the governed evidence library.

The catalogue is designed to support a connected set of cosmetic and performance benefits. No whole-line clinical study is registered. Every result below remains attached to the exact current product or regimen that earned it.

the current catalogue map

Eight benefit territories, one day-to-night rhythm

Use these territories to find the product job first. Then open the exact product, directions, and evidence rather than treating the catalogue as one undifferentiated formula.

Lips

long-wear color · finish and shine · lip definition · comfort care · precision removal

Eyes, brows & lashes

eye color · liner definition · lash volume and wear · brow shape and fullness · under-eye brightening

Face color

prime · even visible tone · build coverage · correct contrast · add cheek color · sculpt · highlight · set the finish

Hair & scalp

cleanse hair and scalp · reset buildup · detangle and prime · support the look of density, strength, or volume · refresh between washes

Nails

prepare the nail surface · add color · seal shine · condition cuticles · support a smoother-looking finish

Wellness & oral care

collagen supplementation · sleep-routine support as labeled · topical magnesium formats · daily oral care

current evidence · 3 registered claims

LipSense Cream (tested as LipSense Hydra Matte Lip Color)

claim 01measured clinical result

At 4 hours, mean LipSense Cream appearance scores were 3.2 by trained-technician assessment and 3.4 by participant assessment on the study's 0-to-4 scale.

Scope
LipSense Hydra Matte Lip Color tested article, presented as LipSense Cream
Endpoint
mean lip-appearance score on the study's 0-to-4 scale
Duration
4 hours after application
Source
Essex Testing Clinic, Panel 23076 / Entry 50474, n=32; final report April 4, 2023
claim 02measured clinical result

In the LipSense Cream forearm protocol, the mean product-transference score after rubbing was 0.4 on the study's 0-to-9 scale.

Scope
LipSense Hydra Matte Lip Color tested article, presented as LipSense Cream; 2 cm by 2 cm forearm site rubbed with a white towel
Endpoint
mean product-transference score on the study's 0-to-9 scale
Duration
approximately 5 minutes after application
Source
Essex Testing Clinic, Panel 23076 / Entry 50474, n=32; final report April 4, 2023
claim 03measured clinical result

After approximately 30 seconds of water exposure, all LipSense Cream technician and participant mean appearance scores remained 4.0 for both lips and forearm.

Scope
LipSense Hydra Matte Lip Color tested article, presented as LipSense Cream; lips splashed with water and forearm submerged in 27 degrees C water
Endpoint
mean appearance score after the specified brief water-exposure protocols
Duration
approximately 30 seconds of water exposure
Source
Essex Testing Clinic, Panel 23076 / Entry 50474, n=32; final report April 4, 2023

current evidence · 5 registered claims

Evening Moisturizer - Normal to Dry surface-turnover study

claim 01measured clinical result

The treated SenePlex+ formula site showed 49% greater visible surface-cell turnover than the untreated control site at day 13.

Scope
Evening Moisturizer Normal to Dry SGF21090-01 treated site versus untreated control
Endpoint
visible surface-cell turnover
Duration
20-day study; day-13 endpoint
Source
Essex Testing Clinic, Panel 22107, n=33; SENEPLEX-01-MASTER-DATA-TRUTH.md
claim 02measured clinical result

The treated SenePlex+ formula site showed 80% greater visible surface-cell turnover than the untreated control site at day 16.

Scope
Evening Moisturizer Normal to Dry SGF21090-01 treated site versus untreated control
Endpoint
visible surface-cell turnover
Duration
20-day study; day-16 endpoint
Source
Essex Testing Clinic, Panel 22107, n=33; SENEPLEX-01-MASTER-DATA-TRUTH.md
claim 03measured clinical result

The treated SenePlex+ formula site showed 94% greater visible surface-cell turnover than the untreated control site at day 17.

Scope
Evening Moisturizer Normal to Dry SGF21090-01 treated site versus untreated control
Endpoint
visible surface-cell turnover
Duration
20-day study; day-17 endpoint
Source
Essex Testing Clinic, Panel 22107, n=33; SENEPLEX-01-MASTER-DATA-TRUTH.md
claim 04measured clinical result

In an independent 20-day study, a tested SenePlex+ Evening Moisturizer formula showed up to 100% greater visible surface-cell turnover than untreated skin by day 18.

Scope
Evening Moisturizer Normal to Dry SGF21090-01 treated site versus untreated control; not the 8-week regimen
Endpoint
visible surface-cell turnover
Duration
20-day study; day-18 endpoint
Source
Essex Testing Clinic, Panel 22107, n=33, p<0.001; bible-current.txt:853-855
claim 05measured clinical result

Mean time to full visible surface turnover was 15.5 ± 0.4 days at the treated site versus 18.0 ± 0.4 days at the untreated control site.

Scope
Evening Moisturizer Normal to Dry SGF21090-01 treated site versus untreated control
Endpoint
mean time to full visible surface turnover
Duration
20-day study
Source
Essex Testing Clinic, Panel 22107, n=33, p<0.001; SENEPLEX-01-MASTER-DATA-TRUTH.md

current named regimen · 16 registered claims

Normal-to-Dry three-product SenePlex+ regimen

claim 01measured clinical result

The tested SenePlex+ regimen improved measured hydration by 49.99% immediately after application.

Scope
Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen used together
Endpoint
measured hydration versus baseline
Duration
immediate
Source
Validated Claim Support LLC, CS211017, n=32, Corneometer, p<0.001
claim 02measured clinical result

The tested SenePlex+ regimen improved measured hydration by 12.5% at week 2.

Scope
Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen used together
Endpoint
measured hydration versus baseline
Duration
2 weeks
Source
Validated Claim Support LLC, CS211017, n=32, Corneometer, p<0.001
claim 03measured clinical result

The tested SenePlex+ regimen improved measured hydration by 12.0% at week 4.

Scope
Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen used together
Endpoint
measured hydration versus baseline
Duration
4 weeks
Source
Validated Claim Support LLC, CS211017, n=32, Corneometer, p<0.001
claim 04measured clinical result

The tested SenePlex+ regimen improved measured hydration by 28.62% at 8 weeks.

Scope
Normal-to-Dry 3-in-1 Cleanser, DayTime Moisturizer, and Evening Moisturizer regimen used together
Endpoint
measured hydration versus baseline
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, Corneometer, p<0.001
claim 05measured clinical result

The tested SenePlex+ regimen improved measured firmness by 7.06% at week 2 on the Cutometer R0 parameter, where a lower value indicates firmer skin.

Scope
Normal-to-Dry regimen used together
Endpoint
measured firmness
Duration
2 weeks
Source
Validated Claim Support LLC, CS211017, Cutometer R0, p=0.016
claim 06measured clinical result

The tested SenePlex+ regimen improved measured firmness by 6.59% at week 8 on the Cutometer R0 parameter, where a lower value indicates firmer skin.

Scope
Normal-to-Dry regimen used together
Endpoint
measured firmness
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, Cutometer R0, p=0.033
claim 07measured clinical result

At week 8, expert grading found improved visible brightness, radiance, or luminosity in 96.88% of subjects using the tested regimen.

Scope
Normal-to-Dry regimen used together
Endpoint
expert-graded visible brightness, radiance, or luminosity
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, expert grading, p<0.001
claim 08measured clinical result

At week 8, expert grading found improved visible firmness in 80.65% of subjects using the tested regimen.

Scope
Normal-to-Dry regimen used together
Endpoint
expert-graded visible firmness
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, expert grading, p<0.001
claim 09measured clinical result

At week 8, expert grading found improved visible texture or smoothness in 71.88% of subjects using the tested regimen.

Scope
Normal-to-Dry regimen used together
Endpoint
expert-graded visible texture and smoothness
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, expert grading, p<0.001
claim 10measured clinical result

At week 8, expert grading found improved visible tone evenness in 56.25% of subjects using the tested regimen.

Scope
Normal-to-Dry regimen used together
Endpoint
expert-graded visible tone evenness
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, expert grading, p<0.001
claim 11measured clinical result

At week 8, expert grading found improvement in the appearance of fine lines or wrinkles in 31.25% of subjects using the tested regimen.

Scope
Normal-to-Dry regimen used together
Endpoint
expert-graded appearance of fine lines and wrinkles
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, expert grading, p≤0.012
claim 12participant-perception result

At week 8, 100% of subjects agreed that skin felt more moisturized.

Scope
Normal-to-Dry regimen used together
Endpoint
consumer agreement: skin feels more moisturized
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, consumer perception
claim 13participant-perception result

At week 8, 100% of subjects agreed that skin tone looked more supple.

Scope
Normal-to-Dry regimen used together
Endpoint
consumer agreement: skin tone looks more supple
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, consumer perception
claim 14participant-perception result

At week 8, 100% of subjects agreed that skin texture felt smoother.

Scope
Normal-to-Dry regimen used together
Endpoint
consumer agreement: skin texture feels smoother
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, consumer perception
claim 15participant-perception result

At week 8, 96.88% of subjects agreed that skin looked more luminous, radiant, or bright.

Scope
Normal-to-Dry regimen used together
Endpoint
consumer agreement: skin looks more luminous, radiant, or bright
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, consumer perception
claim 16participant-perception result

At week 8, 96.88% of subjects said they would buy the tested product regimen.

Scope
Normal-to-Dry regimen used together
Endpoint
consumer purchase intent
Duration
8 weeks
Source
Validated Claim Support LLC, CS211017, n=32, consumer perception

current evidence · 2 registered claims

SeneCell SenePlex+ StemCell Concentrate

claim 01measured clinical result

In an independent study, SeneCell improved measured skin hydration by up to 73.9% immediately after application.

Scope
SeneCell finished product
Endpoint
measured skin hydration
Duration
immediate
Source
Essex Testing Clinic, Panel 26025, SGF25001-01, n=31, Corneometer, p<0.001
claim 02measured clinical result

In an independent study, SeneCell improved measured skin hydration by 56.4% at 8 weeks.

Scope
SeneCell finished product
Endpoint
measured skin hydration
Duration
8 weeks
Source
Essex Testing Clinic, Panel 26025, SGF25001-01, n=31, Corneometer, p<0.001

current evidence · 3 registered claims

G.L.P-Complex with SenePlex+ and Exosomes

claim 01measured clinical result

In an independent study, G.L.P-Complex reduced the appearance of deep wrinkles by 11.2% at 4 weeks.

Scope
G.L.P-Complex finished product
Endpoint
appearance of deep wrinkles
Duration
4 weeks
Source
Essex Testing Clinic, Panel 26026, SGF25015-01, n=31, image analysis, p<0.001
claim 02measured clinical result

In an independent study, G.L.P-Complex reduced the appearance of deep wrinkles by 23.4% at 8 weeks.

Scope
G.L.P-Complex finished product
Endpoint
appearance of deep wrinkles
Duration
8 weeks
Source
Essex Testing Clinic, Panel 26026, SGF25015-01, n=31, image analysis, p<0.001
claim 03measured clinical result

In an independent study, G.L.P-Complex improved the look of facial volume by 8.4% at 8 weeks.

Scope
G.L.P-Complex finished product
Endpoint
look of facial volume
Duration
8 weeks
Source
Essex Testing Clinic, Panel 26026, SGF25015-01, n=31, image analysis, p=0.044

current evidence · 1 registered claim

NeoTight Rejuvenating Anti-Wrinkle Serum

claim 01measured clinical result

In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application.

Scope
Rejuvenating Anti-Wrinkle Serum finished product
Endpoint
measured net skin elasticity
Duration
baseline to 1 hour after a single application
Source
Validated Claim Support LLC, CS201033 / RE201033.V02, pp.5 and 21, Cutometer R5, Baseline to 1 Hour, n=32, p=0.015

current evidence · 8 registered claims

C-Bright Dark Spot Corrector

claim 01measured clinical result

In an independent study, C-Bright improved the appearance of skin brightness by 2.3% at 4 weeks.

Scope
C-Bright Dark Spot Corrector finished product
Endpoint
image-analyzed appearance of skin brightness
Duration
4 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, n=34, p=0.001
claim 02measured clinical result

In an independent study, C-Bright improved the appearance of skin brightness by 5.0% at 8 weeks.

Scope
C-Bright Dark Spot Corrector finished product
Endpoint
image-analyzed appearance of skin brightness
Duration
8 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, n=34, p<0.001
claim 03measured clinical result

At 8 weeks, 88% of subjects improved on the image-analyzed skin-brightness endpoint.

Scope
C-Bright Dark Spot Corrector finished product
Endpoint
subjects improving on image-analyzed skin brightness
Duration
8 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, n=34
claim 04measured clinical result

In an independent study, C-Bright improved the appearance of hyperpigmentation by 2.6% at 4 weeks.

Scope
C-Bright hyperpigmentation sub-panel
Endpoint
image-analyzed appearance of hyperpigmentation
Duration
4 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, subjects 1–21, p=0.005
claim 05measured clinical result

In an independent study, C-Bright improved the appearance of hyperpigmentation by 2.5% at 8 weeks.

Scope
C-Bright hyperpigmentation sub-panel
Endpoint
image-analyzed appearance of hyperpigmentation
Duration
8 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, subjects 1–21, p=0.021
claim 06measured clinical result

Seventy-six percent of subjects in the C-Bright hyperpigmentation sub-panel improved at the measured endpoints.

Scope
C-Bright hyperpigmentation sub-panel
Endpoint
subjects improving on image-analyzed hyperpigmentation
Duration
4 and 8 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, subjects 1–21
claim 07measured clinical result

In an independent study, C-Bright improved the appearance of dark acne scars by 1.2% at 8 weeks.

Scope
C-Bright dark-acne-scar sub-panel
Endpoint
image-analyzed appearance of dark acne scars
Duration
8 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, subjects 22–34, p=0.016
claim 08measured clinical result

In an independent study, C-Bright evened the appearance of skin tone by 0.3% at 8 weeks.

Scope
C-Bright Dark Spot Corrector finished product
Endpoint
image-analyzed appearance of skin-tone evenness
Duration
8 weeks
Source
Essex Testing Clinic, Panel 23049, ImagePro analysis, n=34, p=0.041

current evidence · 9 registered claims

Current EyeCrème

claim 01clinical summary

In an eight-week independent clinical study of current EyeCrème, 87.10% of participants showed measured improvement in eye-area skin radiance and 64.52% showed a measured decrease in eye-area wrinkle appearance.

Scope
current EyeCrème finished product
Endpoint
visible eye-area radiance and wrinkle appearance
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; 31-participant expert-grading and Visioscan summary
claim 02measured clinical result

After eight weeks with current EyeCrème, 87.10% of participants showed measured improvement in skin radiance in the eye area.

Scope
current EyeCrème finished product
Endpoint
participant responder rate for measured eye-area skin-radiance improvement
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; independent clinical study, n=31, expert grading and Visioscan analysis compared with baseline
claim 03measured clinical result

After eight weeks with current EyeCrème, 64.52% of participants showed a measured decrease in the appearance of wrinkles in the eye area.

Scope
current EyeCrème finished product
Endpoint
participant responder rate for measured decrease in eye-area wrinkle appearance
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; independent clinical study, n=31, expert grading and Visioscan analysis compared with baseline
claim 04participant-perception result

After eight weeks with current EyeCrème, 83.87% of consumer-study participants agreed that their lines and wrinkles appeared diminished.

Scope
current EyeCrème finished product; separate consumer-perception study
Endpoint
participant agreement that lines and wrinkles appeared diminished
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; independent consumer study, n=31; percentage reflects participants who agreed with the statement
claim 05participant-perception result

After eight weeks with current EyeCrème, 80.65% of consumer-study participants agreed that their eye area looked more rested.

Scope
current EyeCrème finished product; separate consumer-perception study
Endpoint
participant agreement that the eye area looked more rested
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; independent consumer study, n=31; percentage reflects participants who agreed with the statement
claim 06participant-perception result

After eight weeks with current EyeCrème, 77.42% of consumer-study participants agreed that their eye area looked smoother and more awake.

Scope
current EyeCrème finished product; separate consumer-perception study
Endpoint
participant agreement that the eye area looked smoother and more awake
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; independent consumer study, n=31; percentage reflects participants who agreed with the statement
claim 07participant-perception result

After eight weeks with current EyeCrème, 74.19% of consumer-study participants agreed that their eye area looked more radiant.

Scope
current EyeCrème finished product; separate consumer-perception study
Endpoint
participant agreement that the eye area looked more radiant
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; independent consumer study, n=31; percentage reflects participants who agreed with the statement
claim 08participant-perception result

After eight weeks with current EyeCrème, 70.97% of consumer-study participants agreed that their eye area looked refreshed and less crepey.

Scope
current EyeCrème finished product; separate consumer-perception study
Endpoint
participant agreement that the eye area looked refreshed and less crepey
Duration
8 weeks
Source
Current official US EyeCrème product page, verified 2026-07-10; independent consumer study, n=31; percentage reflects participants who agreed with the statement
claim 09safety finding

Current EyeCrème is ophthalmologist-tested and described as safe for contact-lens wearers.

Scope
current EyeCrème finished product
Endpoint
eye-area and contact-lens-wearer suitability
Duration
current product safety statement
Source
Current official US EyeCrème product page, verified 2026-07-10