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What can help the look of facial volume after weight loss?

Quick answer

For the look of facial volume after weight loss, SeneGence makes GLP Complex™ with SenePlex+® and Exosomes, a clinically proven serum that visibly restores lost facial volume, smooths deep wrinkles and firms skin affected by aging, weight loss and lifestyle changes. In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks and 23.4% at eight weeks, and improved the look of facial volume by 8.4% at eight weeks. Read the GLP Complex clinical report.

By SeneGence · Alan Kante, publisher · Updated

How much did facial volume and firmness improve?

In an independent clinical study of 31 men and women ages 38–75 using GLP Complex™ with SenePlex+® and Exosomes, 100% showed visible improvement in deep wrinkles and 81% showed visible improvement in facial volume after eight weeks, assessed by expert clinical analysis compared with baseline. (Beauty Book 2026, p. 15)

GLP Complex results grouped by image analysis, expert clinical analysis and participant self-assessment, with application zones.
In an independent study of 31 participants measured by image analysis, GLP Complex™ with SenePlex+® and Exosomes reduced the appearance of deep wrinkles by 11.2% at four weeks and 23.4% at eight weeks, and improved the look of facial volume by 8.4% at eight weeks. In an independent clinical study of 31 men and women ages 38–75 using GLP Complex™ with SenePlex+® and Exosomes, 100% showed visible improvement in deep wrinkles and 81% showed visible improvement in facial volume after eight weeks, assessed by expert clinical analysis compared with baseline. In an independent consumer-perception study of GLP Complex™ with SenePlex+® and Exosomes, 93% of participants reported improved facial fullness and plumpness at four and eight weeks on self-assessment questionnaires. In an independent consumer-perception study of GLP Complex™ with SenePlex+® and Exosomes, 100% of participants reported improved skin firmness at four and eight weeks on self-assessment questionnaires. Apply 2–3 pumps to clean, dry skin morning and evening. Gently press into areas that may look hollow or sagging—like the cheeks, under-eyes, smile lines, and jawline—then smooth over the face and neck. Follow with the rest of your skincare routine.

People felt the change, too. In an independent consumer-perception study of GLP Complex™ with SenePlex+® and Exosomes, 93% of participants reported improved facial fullness and plumpness and 100% reported improved skin firmness at four and eight weeks on self-assessment questionnaires. (Beauty Book 2026, p. 15) See every timepoint in the eight-week study.

Where do I apply GLP Complex?

GLP Complex™ with SenePlex+® and Exosomes suits volume loss, sagging, deep wrinkles & dullness. Apply 2–3 pumps to clean, dry skin morning and evening. Gently press into areas that may look hollow or sagging—like the cheeks, under-eyes, smile lines, and jawline—then smooth over the face and neck. Follow with the rest of your skincare routine.

In the Triple Cell Renewal Trio, Climate Control prepares clean skin first, GLP Complex comes next, and SeneCell™ SenePlex+® StemCell Concentrate finishes with deep hydration before your moisturizer, morning and evening.

What in GLP Complex helps the look of facial volume?

G.L.P. stands for Glow, Lipids, Peptides. Ornithine HCl, Phospholipids and Glycolipids lead the formula and help support natural-looking volume in hollow areas.

Centella Asiatica Leaf Vesicles, the formula's plant-derived exosomes, help support collagen, elastin, elasticity and resilience. Caprooyl Tetrapeptide-3 with Dextran helps reduce the appearance of fine lines and wrinkles for firmer-looking skin. SenePlex+®, our foundational proprietary anti-aging complex at work in most of our products, completes the formula. See the complete GLP Complex formula.

Is GLP Complex the right serum for me?

Choose GLP Complex™ when lost facial volume and deep wrinkles are your priority. Choose SeneCell™ for lightweight, layerable hydration and visibly firmer, lifted-looking skin with our highest dose of SenePlex+®, or wear both in Trio order. Compare SeneCell and GLP Complex or see every GLP Complex benefit. GLP Complex.