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Science & Ingredients

What Peptides Are in SeneGence Products? Exact INCI Guide

SeneGence formulas use exact peptides for distinct cosmetic jobs: Caprooyl Tetrapeptide-3 and Palmitoyl Tripeptide-1 for smoother-looking skin, Acetyl Tetrapeptide-3 for fuller-looking brows and lashes, Myristoyl Pentapeptide-17 for the lash line, and copper and Nicotiana peptides in facial care. See the exact current formula beside each INCI before choosing a product.

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Caprooyl Tetrapeptide-3 with Dextran

For smoother-looking lines and firmer-looking skin, look for Caprooyl Tetrapeptide-3 with Dextran in GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate, and MakeSense® Silk Primer & Pore Minimizer.

how to use it

Choose by routine job: GLP Complex for targeted line-and-contour care, SeneCell for concentrated hydration, or Silk Primer for a smoother-looking base before complexion makeup.

the science

Human serum studies used the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material; separate cell and explant studies tested Caprooyl Tetrapeptide-3.

Atrium Innovations reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3.

The evidence page also covers longer-term ultrasound, consumer, cell, and skin-explant findings. Read the complete Caprooyl Tetrapeptide-3 evidence.

Acetyl Tetrapeptide-3 with Clover and Dextran

For fuller-looking brows, lashes, and hair, look for Acetyl Tetrapeptide-3 with Trifolium Pratense (Clover) Flower Extract and Dextran in BrowSense® Volumizing Brow Gel, HairCovery® Strengthening & Thickening Hair Serum, LashSense® VolumeIntense® Mascara, LashSense® VolumeIntense® Waterproof Mascara, and UnderSense® 3-in-1 Maximizing Lash Primer.

how to use it

Match the format to the beauty goal: BrowSense shapes and holds, HairCovery is the leave-on scalp-serum step, UnderSense primes and builds lashes, and one regular or waterproof VolumeIntense mascara supplies the color finish.

the science

Clariant reports fuller-looking lash and hair findings across distinct human studies, with supportive follicle and scalp-microbiome work.

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening.

Open the complete hair, lash, follicle, and scalp evidence.

The Two-Peptide Tone Pair

For more even-looking tone and lighter-looking dark spots, look for Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1.

how to use it

You will find the pair in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, DayTime Moisturizer - Normal to Oily, Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Oily. Choose among these six US formulas by your skin type, the texture you enjoy and the time of day.

the science

The ingredient manufacturer describes Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1 for more even-looking tone and lighter-looking dark spots. It also reports a 56-day study of the pair.

See the two-peptide tone role.

Plant-Produced Peptide Night Care

For smoother, firmer, more radiant-looking night care, look for Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 in the current US formulas of Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily.

how to use it

The ingredient manufacturer describes producing this fusion peptide through Nicotiana benthamiana biotechnology and vertical farming. You will find it in three US night creams—Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry and Evening Moisturizer - Normal to Oily—so choose the texture for your skin type.

the science

In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average.

The research also examines firmness, elasticity, radiance, hydration, pores, roughness, skin thickness, barrier-associated genes, collagen and skin explants. Read the fusion-peptide evidence.

Five Recombinant Factors in Advanced Renewal

For multi-factor smoothing and visible renewal, Advanced SenePlex+® Renewal Serum with Retinol combines sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11.

how to use it

Choose this evening facial treatment when you want retinol, the five-factor complex, and a separate Palmitoyl peptide pair in one visible-renewal formula.

the science

Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, LABIO reports appearance improvement of 10% at two weeks and 21% at four weeks.

For the material containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, LABIO reports a below-eye wrinkle image-analysis measure improved 38% at two weeks and 46% at four weeks.

See the five-factor findings.

Expression-Line Peptide in NeoTight Rejuvenating

For softer-looking expression lines and smoother, less shiny-looking skin, NeoTight® Rejuvenating Anti-Wrinkle Serum contains Dipeptide Diaminobutyroyl Benzylamide Diacetate.

the science

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, dsm-firmenich reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily.

The evidence page also covers user-reported smoothness and shine plus the manufacturer’s cell and biochemical work. Read the dipeptide evidence.

Palmitoyl Tripeptide-1 in Skin and Lip Care

For smoother-looking renewal, Advanced SenePlex+® Renewal Serum with Retinol pairs Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7.

For hydrated, smoother, fuller-looking lips, LipSense® Long-Lasting Lip Liner Pencil carries Palmitoyl Tripeptide-1 in a separate lip-care context.

how to use it

Choose by zone and finish: Advanced Renewal is a facial treatment serum, while Lip Liner gives precise definition with conditioning lip care.

the science

On its current manufacturer page, Sederma positions the exact Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 pair for smoother-looking skin and visible repair.

See the smoothing pair.

For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, Sederma reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in an uncontrolled 10-woman study of a colorless lipstick containing 1% material, used three times daily.

For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, Sederma reports that the 10 participants noticed improved lip condition and smoothness with less flaking at day 29 after using the 1% material colorless lipstick three times daily.

Read the lip-care study.

The Lip Line Corrector Peptide Pair

For smoother-looking deep lip-area folds and plumper-looking contours, Lip Line Corrector pairs Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate.

how to use it

Use it as the targeted lip-area step when the look of vertical lines and deeper folds beside the mouth leads your choice.

the science

For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, Infinitec Activos reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material.

See the deep-fold evidence.

Myristoyl Pentapeptide-17 in LashExtend

For denser, fuller-looking lashes, LashExtend contains Myristoyl Pentapeptide-17.

how to use it

Choose LashExtend as the dedicated lash-serum format, applied at the lash base morning and evening as directed until the desired result.

the science

For Myristoyl Pentapeptide-17, Symrise reports induction of hair-specific keratin genes after 48 hours in an in vitro human keratinocyte assay using 0.001% neat material.

For Myristoyl Pentapeptide-17, Symrise’s conclusion slide reports increasing lash density through day 42, with values of 33.67% at day 14, 46.71% at day 28, and 60.60% at day 42 in a four-person uncontrolled lash-root study testing 5% and 10% supplier-material eyeliner serums once nightly; allocation between strengths and whether or how the conclusion series combines them are not disclosed.

For Myristoyl Pentapeptide-17, Symrise labels a single right-eyelash image series for its 10% supplier-material eyeliner-serum example with increases of 46.26% at day 14, 66.3% at day 28, and 72.29% at day 42.

See the lash-peptide evidence.

Biotinoyl Tripeptide-1 with Panthenol in UnderSense

For longer-, fuller-, stronger-looking lash support, UnderSense® 3-in-1 Maximizing Lash Primer contains Biotinoyl Tripeptide-1.

how to use it

Apply UnderSense to top and bottom lashes, add coats for more buildable length and volume, and let it fully dry before finishing with one VolumeIntense mascara.

the science

The manufacturer material combines Glycerin, Water, Panthenol, and Biotinoyl Tripeptide-1.

Sederma describes longer-, fuller-, stronger-looking lashes for the full Glycerin, Water, Panthenol, and Biotinoyl Tripeptide-1 ingredient combination in its current summary.

See the lash-support role.

Oligopeptide-10 and Skin-Clarity Research

UnderSense® 3-in-1 Maximizing Lash Primer also lists Oligopeptide-10. Helix BioMedix reports cosmetic skin-clarity research for this exact peptide.

how to use it

For the customer routine, UnderSense supplies a light-beige preparation layer, buildable volume and length, and a base for mascara. Let it fully dry before the color finish.

the science

For Oligopeptide-10, Helix BioMedix reports C. acnes activity and improved appearance of blemishes and red blotchy spots in an ingredient-research summary based on data on file.

Read the Oligopeptide-10 research.

Copper Peptide in DayTime Moisturizers

For firming and line care in daytime moisture, look for Bis(Tripeptide-1) Copper Acetate in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, and DayTime Moisturizer - Normal to Oily.

how to use it

Choose one DayTime texture for your skin: richer comfort for Dry, balanced hydration for Normal to Dry, or hydration with a more matte T-zone for Normal to Oily.

the science

The ingredient manufacturer describes Bis(Tripeptide-1) Copper Acetate for firmer-looking skin and wrinkle care, citing several controlled facial studies.

See the copper-peptide source.

Acetyl Hexapeptide-8 in Translucent Loose Powder

Translucent Loose Powder creates a soft-focus setting finish. Its formula also includes Acetyl Hexapeptide-8.

how to use it

Pick up the loose powder with a brush and apply where you want a soft-focus finish.

the science

The manufacturer studies used leave-on cream test articles, while Translucent Loose Powder is the current SeneGence formula where this exact INCI appears.

For Acetyl Hexapeptide-8, Lipotec/Lubrizol reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily.

For Acetyl Hexapeptide-8, Lipotec/Lubrizol reports wrinkle roughness 20.4% lower at day 28 in an uncontrolled instrumental study of 18 women using a leave-on cream with 5% supplier solution twice daily.

For Acetyl Hexapeptide-8, Lipotec/Lubrizol reports up to 32% lower glutamate release at 2 mM in an in vitro assay.

Read the Acetyl Hexapeptide-8 studies.

Choose a Peptide Routine by Goal

For facial lines, contour, and daypart moisture, follow the complete treatment order and finish with one moisturizer selected for your skin.

For lashes, let UnderSense® fully dry, then choose one VolumeIntense® mascara finish.

how to use it

The complete facial order is Cleanse → Climate Control → GLP Complex → SeneCell → one DayTime or Evening moisturizer chosen for skin type → eye care. For lashes, use UnderSense as the preparation layer, then choose regular VolumeIntense for humidity- and smudge-resistant color or Waterproof when sweat, tears, or water resistance matters.

the science
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