What is SeneGence Advanced SenePlex+® Renewal Serum with Retinol?

How does it work overnight?

We made it for transformative retinol results, without the irritation. Advanced SenePlex+® Renewal Serum with Retinol smooths the look of lines, texture and discoloration overnight with encapsulated Retinyl Palmitate, targeted peptides and growth factors. A lipid shell holds that Retinyl Palmitate for sustained overnight release, and together with the peptides and five growth factors it helps stimulate collagen, accelerate cell turnover and reduce the appearance of wrinkles and discoloration as you sleep. Beauty Book 2026 (p. 16).

What results did women see?

Women saw more than a younger-looking face. In a six-week independent consumer study, 85% of women agreed that Advanced SenePlex+® Renewal Serum with Retinol improved their skin’s overall appearance and 85% that it helped their skin feel firmer; 82% agreed it improved skin clarity, leaving a healthy, even tone; 76% that it reduced the appearance of crow’s feet around their eyes; and 73% that it minimized the appearance of fine lines and wrinkles. Beauty Book 2026 (p. 16).

What is inside?

Retinyl Palmitate at 0.5% provides encapsulated vitamin A care for lines, tone and texture overnight, with Retinol beside it as a second form of vitamin A for brighter, firmer-looking skin and less noticeable fine lines. The serum’s retinol is micro-encapsulated for sustained release. Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 help support elasticity for firmer-looking skin, and their maker pairs them for smoother-looking skin and visible repair; each peptide carries palmitic acid, the palmitoyl in its name. The five growth factors—sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-11 and sh-Polypeptide-9—targets the appearance of lines, wrinkles and sagging. Nephelium Lappaceum (Rambutan) Leaf Extract complements retinol's activity. Advanced SenePlex+® Renewal Serum with Retinol pairs aloe leaf juice with meadowfoam seed oil and hyaluronates for hydrating, calming care. Explore the serum’s Aloe Vera. Explore Retinol, the smoothing peptide pair and the rambutan leaf.

Where does SenePlex+® come in?

SenePlex+® is our foundational proprietary anti-aging complex, at work in most of our products, and our extremophile technology, made with extracts and cells that survive in extreme environments. In this serum, Orchis Mascula (Orchid) Flower Extract hydrates and conditions for resilient-looking skin, the bioferments Saccharomyces Cerevisiae (Yeast) Extract and Laminaria Digitata (Kelp) Extract give a gently renewed look, and Sodium Hyaluronate, a form of hyaluronic acid, joins Glucosamine HCl, Urea, Panthenol and vitamin E for moisture and comfort. On Joni Rogers-Kante’s search for extremophile organisms in Vanuatu, the orchid of the Mount Yasur caldera inspired SenePlex+®. Discover SenePlex+®.

How and when do I use it?

Apply 1-2 pumps of the product onto clean face, concentrating on areas of concern. Follow with SeneGence Evening Moisturizer. Start using every other night and increase to nightly use as tolerated. Use a broad-spectrum sunscreen with a minimum of SPF 15 and avoid sun exposure while using retinol. For external use only. Avoid contact with eyes. If contact occurs, rinse thoroughly with water. Discontinue use if signs of irritation or rash appear. Keep out of the reach of children. In your evening routine, it is the advanced anti-aging treatment, applied after cleansing. Advanced SenePlex+® Renewal Serum with Retinol suits all skin types, especially visible signs of aging. Start retinol comfortably, see where SPF goes in the morning or see how retinol and vitamin C share a routine. Read the official ingredients and directions.