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Choosing products

What copper peptides does SeneGence use?

Quick answer

SeneGence brings copper to firmer-looking skin two ways: Bis(Tripeptide-1) Copper Acetate, the copper peptide in all three DayTime Moisturizers, and Copper Lysinate/Prolinate, a copper complex paired with Methylglucoside Phosphate in NeoTight® Rejuvenating Anti-Wrinkle Serum. In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application. See the NeoTight Rejuvenating results.

  • 3 min read

How do the two copper ingredients compare?

Each copper ingredient sits in its own finished formula; choose the formula for the job you want.
What you want to knowBis(Tripeptide-1) Copper AcetateCopper Lysinate/ProlinateExplore
What it isA copper peptide.A copper complex of the amino acids lysine and proline, paired with Methylglucoside Phosphate.The copper-peptide source · Beauty Book 2026
Where you find itDayTime Moisturizer – Dry, Normal to Dry and Normal to Oily.NeoTight® Rejuvenating Anti-Wrinkle Serum.See every peptide by goal
Its beauty jobFirmer-looking skin inside your daily morning moisture.A plumper, more youthful appearance inside a treatment serum.NeoTight Rejuvenating results

Where is the copper peptide?

DayTime Moisturizer – Dry includes Bis(Tripeptide-1) Copper Acetate for firmer-looking skin. This copper-linked peptide also appears in DayTime Moisturizer – Normal to Dry and Normal to Oily; choose the texture for your skin. The ingredient’s maker reports several controlled facial studies of Bis(Tripeptide-1) Copper Acetate for firmer-looking skin and wrinkle care. Read the copper-peptide source. After cleansing, the DayTime Moisturizer for your skin type is your morning moisture step and the base for MakeSense® Original Foundation. Shop DayTime Moisturizer – Dry, DayTime Moisturizer – Normal to Dry or DayTime Moisturizer – Normal to Oily.

Where is the copper complex?

In NeoTight® Rejuvenating Anti-Wrinkle Serum, Copper Lysinate/Prolinate works with Methylglucoside Phosphate beside an expression-line peptide and red algae extract. For a plumper, more youthful appearance, Methylglucoside Phosphate with Copper Lysinate/Prolinate, proline and lysine supports collagen and elastin in NeoTight® Rejuvenating Anti-Wrinkle Serum. Dipeptide Diaminobutyroyl Benzylamide Diacetate smooths the look of fine lines and wrinkles and reduces shine. Porphyridium Cruentum (Red Algae) Extract gives an instant tightening effect. Beauty Book 2026 (p. 18). One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin. The finished serum keeps building after the first hour. After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet. See every NeoTight Rejuvenating result. At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles. Read the NeoTight Rejuvenating clinical report. Apply AM and PM to targeted expression lines. Follow with moisturizer. Beauty Book 2026 (p. 18).

Which one should I choose?

Choose a DayTime Moisturizer when you want copper peptide care inside your everyday morning moisture. Add NeoTight Rejuvenating Anti-Wrinkle Serum when lines, firmness and shine are the focus of a treatment step. They share a routine well: treatment serum first, then moisturizer. One more copper ingredient appears in SeneGence formulas. Copper PCA pairs a mineral with PCA, a component used in moisture-care formulas. SeneSerum-C Hydrating C-Pearls® Serum includes it beside the other PCA mineral salts. See Copper PCA. Explore every SeneGence peptide by goal or whether peptides work on skin.

Study results at a glance

NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study20 results
NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study
ResultKind of resultWhen it was measured
In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application.Measured resultbaseline to 1 hour after a single application
One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin.Expert assessment1 hour after a single application
At week 6, 84.38% of participants agreed that they liked how their skin felt immediately after applying Rejuvenating Anti-Wrinkle Serum.Participant feedbackweek-6 questionnaire about immediate application feel
After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet.Expert assessment6 weeks
After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 13.64% average improvement in the appearance of upper-lip lines.Expert assessment6 weeks
Show 15 more results
NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study, more results
ResultKind of resultWhen it was measured
After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 7.14% average improvement in the appearance of nasolabial folds.Expert assessment6 weeks
At week 6, 96.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum hydrated their skin well.Participant feedback6 weeks
At week 6, 87.50% of participants agreed that Rejuvenating Anti-Wrinkle Serum improved their skin's overall appearance.Participant feedback6 weeks
At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles.Participant feedback6 weeks
At week 6, 78.13% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of crow's feet around the eyes.Participant feedback6 weeks
At week 6, 62.50% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of nasolabial folds.Participant feedback6 weeks
At week 6, 71.88% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of upper-lip lines.Participant feedback6 weeks
At week 6, 75.00% of participants agreed that their face appeared more youthful after using Rejuvenating Anti-Wrinkle Serum.Participant feedback6 weeks
At week 6, 75.00% of participants agreed that their skin felt firmer after using Rejuvenating Anti-Wrinkle Serum.Participant feedback6 weeks
At week 6, 71.88% of participants agreed that their skin appeared tighter after using Rejuvenating Anti-Wrinkle Serum.Participant feedback6 weeks
At week 6, 96.88% of participants agreed that their skin tolerated Rejuvenating Anti-Wrinkle Serum well without sensitivities.Participant feedback6 weeks
At week 6, 84.38% of participants agreed that they liked the color, texture, smell, and feel of Rejuvenating Anti-Wrinkle Serum.Participant feedback6 weeks
At week 6, 71.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum absorbed well and did not feel greasy or tacky.Participant feedback6 weeks
At week 6, 87.50% of participants agreed that they liked Rejuvenating Anti-Wrinkle Serum overall.Participant feedback6 weeks
At week 6, 71.88% of participants agreed that they noticed a firmer-looking, more lifted appearance after applying Rejuvenating Anti-Wrinkle Serum.Participant feedbackweek-6 questionnaire about appearance after application
Who took part
n=32 for Cutometer and participant questionnaire; n=31 for expert grading
How it was evaluated
Cutometer MPA 580 R5, expert grading, and participant questionnaire; each endpoint remains separately labeled
Statistical context
Baseline-to-1-hour Cutometer R5 change p=0.015; expert-grading and participant-agreement results are descriptive as reported

See the full finding: NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study · Open the study PDF