Do peptides actually work on skin?

Choose by the change you want to see, then open the linked evidence page for the complete tested material, study design, timepoints, findings, and source.

Which peptide fits the result you want?

• Smoother-looking lines and firmer-looking skin: Caprooyl Tetrapeptide-3 with Dextran appears in GLP Complex™ with SenePlex+® and Exosomes, SeneCell™ SenePlex+® StemCell Concentrate, and MakeSense® Silk Primer & Pore Minimizer. A manufacturer reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3. Read the complete study.
• Fuller-looking brows, lashes, and hair: Acetyl Tetrapeptide-3 with Trifolium Pratense (Clover) Flower Extract and Dextran appears in BrowSense® Volumizing Brow Gel, HairCovery® Strengthening & Thickening Hair Serum, LashSense® VolumeIntense® Mascara, LashSense® VolumeIntense® Waterproof Mascara, and UnderSense® 3-in-1 Maximizing Lash Primer. For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the manufacturer reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening. See the hair and lash evidence.
• More even-looking tone: Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1 appears in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, DayTime Moisturizer - Normal to Oily, Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Oily—the six formulas whose current US ingredient lists verify both peptide names. The ingredient manufacturer describes Palmitoyl sh-Octapeptide-24 Amide with Palmitoyl sh-Tripeptide-5 Norisoleucyl sh-Nonapeptide-1 for more even-looking tone and lighter-looking dark spots. It also reports a 56-day study of the pair. See the two-peptide role.
• Smoother, firmer, more radiant-looking night care: Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76 appears in the current US formulas of Evening Moisturizer - Dry, Evening Moisturizer - Normal to Dry, and Evening Moisturizer - Normal to Oily. The ingredient manufacturer describes producing this fusion peptide through Nicotiana benthamiana biotechnology and vertical farming. In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average. Open the study.
• Multi-factor smoothing and visible renewal: sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11 appear together in Advanced SenePlex+® Renewal Serum with Retinol. Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the manufacturer reports appearance improvement of 10% at two weeks and 21% at four weeks. See the five-factor findings.
• Softer-looking expression lines and less shine: Dipeptide Diaminobutyroyl Benzylamide Diacetate appears in NeoTight® Rejuvenating Anti-Wrinkle Serum. For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the manufacturer reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily. Read the manufacturer evidence.
• Smoother-looking skin and fuller-looking lips: Palmitoyl Tripeptide-1 with Palmitoyl Tetrapeptide-7 appears in Advanced SenePlex+® Renewal Serum with Retinol. On its current source page, the manufacturer positions the exact Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 pair for smoother-looking skin and visible repair. See the facial pair. Separately, Palmitoyl Tripeptide-1 appears in LipSense® Long-Lasting Lip Liner Pencil in a lip-care material. For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the manufacturer reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in an uncontrolled 10-woman study of a colorless lipstick containing 1% material, used three times daily. Read the lip-care study.
• Smoother-looking deep folds beside the mouth: Palmitoyl Tetrapeptide-50 with Heptapeptide-15 Palmitate appears in Lip Line Corrector. For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, the manufacturer reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material. See the deep-fold evidence.
• Denser, fuller-looking lashes: Myristoyl Pentapeptide-17 appears in LashExtend. For Myristoyl Pentapeptide-17, the manufacturer’s conclusion slide reports increasing lash density through day 42, with values of 33.67% at day 14, 46.71% at day 28, and 60.60% at day 42 in a four-person uncontrolled lash-root study testing 5% and 10% supplier-material eyeliner serums once nightly; allocation between strengths and whether or how the conclusion series combines them are not disclosed. See the lash study.
• Longer-, fuller-, stronger-looking lash support: Biotinoyl Tripeptide-1 appears in UnderSense® 3-in-1 Maximizing Lash Primer; the manufacturer material combines it with Panthenol. A manufacturer describes longer-, fuller-, stronger-looking lashes for the full Glycerin, Water, Panthenol, and Biotinoyl Tripeptide-1 ingredient combination in its current summary. See the lash-support role.
• Oligopeptide-10 and skin-clarity research: Oligopeptide-10 also appears in UnderSense® 3-in-1 Maximizing Lash Primer, which prepares lashes for buildable volume before mascara. For Oligopeptide-10, a manufacturer reports C. acnes activity and improved appearance of blemishes and red blotchy spots in an ingredient-research summary based on data on file. See the separate ingredient research.
• Firming and line care with daytime moisture: Bis(Tripeptide-1) Copper Acetate appears in DayTime Moisturizer - Dry, DayTime Moisturizer - Normal to Dry, and DayTime Moisturizer - Normal to Oily. The ingredient manufacturer describes Bis(Tripeptide-1) Copper Acetate for firmer-looking skin and wrinkle care, citing several controlled facial studies. See the copper-peptide source.
• A soft-focus makeup step with Acetyl Hexapeptide-8: Acetyl Hexapeptide-8 appears in Translucent Loose Powder; its manufacturer studies used leave-on cream test articles. For Acetyl Hexapeptide-8, a manufacturer reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily. Read the ingredient studies.

For a facial routine, start with cleansing, then follow each chosen product’s directions and add only the treatment steps your skin and routine call for before moisturizer and eye care. In the morning choose DayTime Dry, Normal to Dry, or Normal to Oily. In the evening choose Evening Dry, Normal to Dry, or Normal to Oily. For lashes, let UnderSense fully dry, then finish with one VolumeIntense Mascara or VolumeIntense Waterproof Mascara.

Explore SeneGence’s peptide guide to compare every peptide ingredient, its formula, the manufacturers’ reported findings, study methods, and original sources.