Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies8 results
Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies
| Result | Kind of result | When it was measured |
| In an in vitro fibroblast assay of Caprooyl Tetrapeptide-3, the ingredient’s maker reports laminin 26% higher and fibronectin 60% higher after 48 hours. | Ingredient study | 48 hours |
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| In a corticoid-stressed four-donor human-skin explant model of Caprooyl Tetrapeptide-3, the ingredient’s maker reports collagen VII staining 34% higher and laminin-5 staining 49% higher versus corticoid alone at day 3. | Ingredient study | day 3 |
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| In the corticoid-stressed four-donor human-skin explant model, the ingredient’s maker reports that Caprooyl Tetrapeptide-3 helped prevent the dermal-epidermal-junction flattening seen with corticoid alone at day 3. | Ingredient study | day 3 |
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| The ingredient’s maker reports 16% average improvement in fine-line and wrinkle appearance at day 28 in a randomized split-temple serum study of Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3. | Ingredient study | day 28 |
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| In the same randomized split-temple serum study, the ingredient’s maker reports that the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material improved fine-line and wrinkle appearance by up to 29% at day 28. | Ingredient study | day 28 |
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Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies, more results
| Result | Kind of result | When it was measured |
| In the age-defined 50–65 subgroup of the same 27-woman randomized split-temple serum study of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material, the ingredient’s maker reports 27% average and up to 35% improvement in fine-line and wrinkle appearance at day 56. | Ingredient study | day 56 |
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| In a separate 30-woman self-assessment of a serum with 2.5% of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material used twice daily, the ingredient’s maker reports favorable perceptions of smoothness, firmness, evenness, and a rested look at day 56, plus favorable eye-area tolerability. | Participant feedback | day 56 |
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| In a 27-woman split-temple ultrasound study of a serum with 2.5% of the full Glycerin, Water, Dextran, and Caprooyl Tetrapeptide-3 material used twice daily, the ingredient’s maker reports improvement versus placebo in 78% of participants on the upper-dermis entropy measure at day 168. | Ingredient study | day 168 |
- Who took part
- Human instrumental study: 27 women ages 40–65; self-assessment: 30 women ages 40–65; explant work: four human skin specimens
- How it was evaluated
- In vitro fibroblast work; four-donor stressed skin-explant work; randomized split-temple serum comparisons measured by silicone-replica profilometry and ultrasound; and a 30-woman self-assessment
- Statistical context
- The manufacturer-authored article reports day-28 wrinkle-appearance improvement in its randomized split-temple serum study.
See the full finding: Caprooyl Tetrapeptide-3 with Dextran — wrinkle and skin-support studies
GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study5 results
- Who took part
- 31 participants
- How it was evaluated
- Image analysis of the finished GLP Complex formula
- Statistical context
- Deep-wrinkle endpoints p<0.001; facial-volume endpoint at eight weeks p=0.044
See the full finding: GLP Complex™ with SenePlex+® and Exosomes — wrinkles and facial-volume study · Open the study PDF
NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study20 results
NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study
| Result | Kind of result | When it was measured |
| In an independent study, Rejuvenating Anti-Wrinkle Serum improved measured net skin elasticity by 7.65% one hour after a single application. | Measured result | baseline to 1 hour after a single application |
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| One hour after a single application of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 12.05% average improvement in firmer-looking skin. | Expert assessment | 1 hour after a single application |
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| At week 6, 84.38% of participants agreed that they liked how their skin felt immediately after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about immediate application feel |
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| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 24.53% average improvement in the appearance of crow’s feet. | Expert assessment | 6 weeks |
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| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 13.64% average improvement in the appearance of upper-lip lines. | Expert assessment | 6 weeks |
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NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study, more results
| Result | Kind of result | When it was measured |
| After six weeks of NeoTight® Rejuvenating Anti-Wrinkle Serum, expert grading of 31 participants found a 7.14% average improvement in the appearance of nasolabial folds. | Expert assessment | 6 weeks |
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| At week 6, 96.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum hydrated their skin well. | Participant feedback | 6 weeks |
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| At week 6, 87.50% of participants agreed that Rejuvenating Anti-Wrinkle Serum improved their skin's overall appearance. | Participant feedback | 6 weeks |
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| At week 6, 84.38% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of fine lines and wrinkles. | Participant feedback | 6 weeks |
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| At week 6, 78.13% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of crow's feet around the eyes. | Participant feedback | 6 weeks |
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| At week 6, 62.50% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of nasolabial folds. | Participant feedback | 6 weeks |
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| At week 6, 71.88% of participants agreed that NeoTight® Rejuvenating Anti-Wrinkle Serum reduced the appearance of upper-lip lines. | Participant feedback | 6 weeks |
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| At week 6, 75.00% of participants agreed that their face appeared more youthful after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
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| At week 6, 75.00% of participants agreed that their skin felt firmer after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
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| At week 6, 71.88% of participants agreed that their skin appeared tighter after using Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
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| At week 6, 96.88% of participants agreed that their skin tolerated Rejuvenating Anti-Wrinkle Serum well without sensitivities. | Participant feedback | 6 weeks |
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| At week 6, 84.38% of participants agreed that they liked the color, texture, smell, and feel of Rejuvenating Anti-Wrinkle Serum. | Participant feedback | 6 weeks |
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| At week 6, 71.88% of participants agreed that Rejuvenating Anti-Wrinkle Serum absorbed well and did not feel greasy or tacky. | Participant feedback | 6 weeks |
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| At week 6, 87.50% of participants agreed that they liked Rejuvenating Anti-Wrinkle Serum overall. | Participant feedback | 6 weeks |
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| At week 6, 71.88% of participants agreed that they noticed a firmer-looking, more lifted appearance after applying Rejuvenating Anti-Wrinkle Serum. | Participant feedback | week-6 questionnaire about appearance after application |
- Who took part
- n=32 for Cutometer and participant questionnaire; n=31 for expert grading
- How it was evaluated
- Cutometer MPA 580 R5, expert grading, and participant questionnaire; each endpoint remains separately labeled
- Statistical context
- Baseline-to-1-hour Cutometer R5 change p=0.015; expert-grading and participant-agreement results are descriptive as reported
See the full finding: NeoTight® Rejuvenating Anti-Wrinkle Serum — one-hour and six-week study · Open the study PDF
Nicotiana fusion peptide — 28-day skin-appearance study10 results
Nicotiana fusion peptide — 28-day skin-appearance study
| Result | Kind of result | When it was measured |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports increased expression of selected genes associated with epidermal lipids and barrier function after 24 and 48 hours in primary human keratinocytes exposed to 20 ng/mL active, stated as 2% material. | Ingredient study | 24 hours; 48 hours |
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| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports dose-responsive collagen I after 48 hours in adult human dermal fibroblasts and describes its assay-specific potency as four times the retinol reference. | Ingredient study | 48 hours |
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| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports qualitative increases in epidermal thickness and lipid staining at day 8 in an exploratory human-skin explant from one 52-year-old donor treated with a cream containing 1.5% material. | Ingredient study | day 8 |
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| In a 20-woman, placebo-controlled split-face study of Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer used a preparation containing 2% material, applied twice daily. At day 28, it reported 16% lower wrinkle count, 11% lower wrinkle volume and 14% lower wrinkle depth across the full study group. Within the separate 85% responder group, wrinkle depth was 19.4% lower on average. | Measured result | day 28 |
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| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort firmness 11% higher and elasticity 6% higher at day 28 in the 20-woman placebo-controlled split-face study using 2% material twice daily; the 95% responder subsets averaged 12.6% and 6.1% higher. | Measured result | day 28 |
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Nicotiana fusion peptide — 28-day skin-appearance study, more results
| Result | Kind of result | When it was measured |
| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort pore diameter 11.6% lower at day 28 in the 20-woman placebo-controlled split-face study; the 80% responder subset averaged 16.2% lower, with improvement up to 44%. | Measured result | day 28 |
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| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort radiance 12.5% higher at day 28 in the 20-woman placebo-controlled split-face study; the 90% responder subset averaged 14.4% higher, with improvement up to 42%. | Measured result | day 28 |
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| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort hydration 12.4% higher and transepidermal water loss 9.5% lower at day 28 in the 20-woman placebo-controlled split-face study; hydration had 100% responders, while the 90% water-loss responder subset averaged 11.2% lower. | Measured result | day 28 |
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| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports whole-cohort skin roughness 6.9% lower at day 28 in the 20-woman placebo-controlled split-face study; the 75% responder subset averaged 12.6% lower, with improvement up to 26%. | Measured result | day 28 |
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| For Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-76, the ingredient manufacturer reports skin thickness 8.0% higher among the 85% responder subset at day 28 in the 20-woman placebo-controlled split-face ultrasound study, with improvement up to 16%. | Measured result | day 28 |
- Who took part
- Human study: 20 women ages 45–65 using 2% supplier material twice daily for 28 days
- How it was evaluated
- Keratinocyte and fibroblast assays, a human skin-explant model, and a 20-woman placebo-controlled split-face study using instrumental wrinkle, firmness, pore, radiance, hydration, and water-loss measures
- Statistical context
- Across the human study, the ingredient manufacturer reports improvements in wrinkles, firmness, radiance, pores, hydration, and water loss at day 28.
See the full finding: Nicotiana fusion peptide — 28-day skin-appearance study · Open the source document (PDF)
Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum2 results
Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum
| Result | Kind of result | When it was measured |
| Using PRIMOS Lite 3D to measure crow’s-feet after use of a cosmetic formula containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports appearance improvement of 10% at two weeks and 21% at four weeks. | Measured result | two weeks; four weeks |
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| For the material containing sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, and sh-Polypeptide-11, the ingredient’s maker reports a below-eye wrinkle image-analysis measure improved 38% at two weeks and 46% at four weeks. | Measured result | two weeks; four weeks |
- Who took part
- The public brochure does not disclose sample size, material concentration, comparator, or cadence
- How it was evaluated
- PRIMOS Lite 3D crow’s-feet measurement and a separate below-eye wrinkle image-analysis measure; public protocol is incomplete
- Statistical context
- The ingredient’s maker reports improvement in crow’s-feet and a separate below-eye wrinkle measure over four weeks.
See the full finding: Five sh-Oligopeptide and sh-Polypeptide factors in Advanced SenePlex+ Renewal Serum · Open the source document (PDF)
Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study4 results
Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study
| Result | Kind of result | When it was measured |
| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports up to 3.5-fold PLOD3 gene-expression induction after 24 hours in fibroblasts from a 63-year-old donor exposed to the exact peptide; this is an in vitro mechanism endpoint. | Measured result | 24 hours |
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| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily. | Ingredient study | day 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles |
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| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports day-28 active-cohort agreement for smoother, less shiny, and more beautiful-looking skin across the three skin-tone groups, plus 83% average confidence agreement among 75 users. | Participant feedback | day 28 |
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| For Dipeptide Diaminobutyroyl Benzylamide Diacetate, the ingredient’s maker reports dose-dependent DPP4 inhibition from 0.8 to 100 ppm in a cell-free biochemical assay. | Measured result | assay time not disclosed |
- Who took part
- Human study: 150 women ages 40–64 across three skin-tone groups; active self-assessment subset: 75 participants
- How it was evaluated
- In vitro gene-expression and biochemical assays; randomized 28-day parallel-group facial study; and active-cohort self-assessment
- Statistical context
- The manufacturer reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7.
See the full finding: Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study · Open the source document (PDF)
Palmitoyl Tripeptide-1 — 29-day lip-care study2 results
Palmitoyl Tripeptide-1 — 29-day lip-care study
| Result | Kind of result | When it was measured |
| For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports hydration 60% higher, superficial wrinkles 29% lower, and 40.7% higher average lip volume at day 29 in an uncontrolled 10-woman study of a colorless lipstick containing 1% material, used three times daily. | Measured result | day 29 |
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| For the full Ethylhexyl Palmitate, Tribehenin, Sorbitan Isostearate, and Palmitoyl Tripeptide-1 material, the ingredient’s maker reports that the 10 participants noticed improved lip condition and smoothness with less flaking at day 29 after using the 1% material colorless lipstick three times daily. | Ingredient study | day 29 |
- Who took part
- 10 women ages 20–40 with thin, small, dry lips
- How it was evaluated
- Human instrumental measures, dermatologist assessment, and participant observation without a separate placebo
- Statistical context
- The ingredient’s maker reports changes in hydration, superficial lip wrinkles, average lip volume, smoothness, and flaking after 29 days.
See the full finding: Palmitoyl Tripeptide-1 — 29-day lip-care study
Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found1 result
Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found
| Result | Kind of result | When it was measured |
| For the exact two-peptide material containing Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate, the ingredient’s maker reports up to 70% lower image-analyzed appearance of deep folds beside the mouth, visible by day 14, in a 28-day study of five adults using 1% material. | Measured result | day 14; day 28 |
- Who took part
- Five adults ages 49–60
- How it was evaluated
- Human instrumental image analysis at days 14 and 28
- Statistical context
- The ingredient’s maker reports visible change by day 14 in its five-adult deep-fold study.
See the full finding: Lip Line Corrector Peptide Pair: What the Palmitoyl Tetrapeptide-50 and Heptapeptide-15 Palmitate Deep-Fold Study Found · Open the source document (PDF)
Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies8 results
Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies
| Result | Kind of result | When it was measured |
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports follicle elongation 58%, 51%, and 87% higher than untreated follicles at days 4, 7, and 11 in an ex vivo assay of 22 treated and 34 untreated follicles from one donor using 1% material. | Measured result | day 4; day 7; day 11 |
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| For exact Acetyl Tetrapeptide-3, the ingredient’s maker reports 47% greater elongation than untreated follicles at day 7 in an ex vivo assay of 15 peptide-treated, 27 minoxidil-reference, and 27 untreated follicles; its stated reference comparison belongs only to that assay. | Measured result | day 7 |
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| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports mean anagen density 9% higher, mean telogen density 42% lower, and anagen-to-telogen ratio 88% higher at day 90 in a 23-person baseline-controlled rinse-off scalp study using 1.5% material in shampoo and conditioner every two days. | Measured result | day 90 |
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| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports the two specified Cutibacterium acnes scalp-microbiome ratios 36% and 62% lower at day 90 in 21 people using the rinse-off regimen. | Measured result | day 90 |
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| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports a 15% favorable anagen-density delta, 52% favorable telogen-density delta, and 79-point between-group anagen-to-telogen-ratio delta after four months in a randomized 29-person leave-on scalp study using 5% material nightly. | Measured result | four months |
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Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies, more results
| Result | Kind of result | When it was measured |
| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening. | Measured result | week 8 |
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| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports 45.5% more new lashes on the active side at week 8 while the placebo side recorded no new lashes in the same 17-woman split-eye study. | Measured result | week 8 |
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| For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, the ingredient’s maker reports lash length increased by up to 0.70 mm at week 4 in the same 17-woman split-eye study and puts the active-side improvement at three times placebo at week 4 and five times placebo at week 8. | Measured result | week 4; week 8 |
- Who took part
- Human studies included 29 leave-on participants, 23 rinse-off participants, 21 microbiome participants, and 17 split-eye lash participants
- How it was evaluated
- Randomized leave-on scalp study, baseline-controlled rinse-off scalp work, scalp-microbiome analysis, split-eye lash imaging, and ex vivo human-hair-follicle assays
- Statistical context
- Across distinct studies, the ingredient’s maker reports fuller-looking hair and lashes, scalp-microbiome changes, and follicle elongation.
See the full finding: Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies · Open the source document (PDF)
Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies3 results
Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies
| Result | Kind of result | When it was measured |
| For Myristoyl Pentapeptide-17, the ingredient’s maker reports induction of hair-specific keratin genes after 48 hours in an in vitro human keratinocyte assay using 0.001% neat material. | Ingredient study | 48 hours |
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| For Myristoyl Pentapeptide-17, the ingredient maker’s conclusion slide reports increasing lash density through day 42, with values of 33.67% at day 14, 46.71% at day 28, and 60.60% at day 42 in a four-person uncontrolled lash-root study testing 5% and 10% supplier-material eyeliner serums once nightly; allocation between strengths and whether or how the conclusion series combines them are not disclosed. | Measured result | day 14; day 28; day 42 |
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| For Myristoyl Pentapeptide-17, the ingredient’s maker labels a single right-eyelash image series for its 10% supplier-material eyeliner-serum example with increases of 46.26% at day 14, 66.3% at day 28, and 72.29% at day 42. | Measured result | day 14; day 28; day 42 |
- Who took part
- Human study: four people across 5% and 10% supplier-material conditions; the conclusion slide does not assign its result series to either strength. A separate 10% image sequence is labeled as one example.
- How it was evaluated
- In vitro human keratinocyte gene-expression assay; uncontrolled four-person lash-root image study; and one separately labeled 10% example image series
- Statistical context
- The ingredient’s maker reports increasing lash density through day 42 in its four-person study and provides one separately labeled 10% example image series.
See the full finding: Myristoyl Pentapeptide-17 — lash-density and keratin-gene studies · Open the source document (PDF)
Acetyl Hexapeptide-8 — split-face wrinkle studies3 results
Acetyl Hexapeptide-8 — split-face wrinkle studies
| Result | Kind of result | When it was measured |
| For Acetyl Hexapeptide-8, the ingredient’s maker reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily. | Measured result | day 7 |
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| For Acetyl Hexapeptide-8, the ingredient’s maker reports wrinkle roughness 20.4% lower at day 28 in an uncontrolled instrumental study of 18 women using a leave-on cream with 5% supplier solution twice daily. | Measured result | day 28 |
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| For Acetyl Hexapeptide-8, the ingredient’s maker reports up to 32% lower glutamate release at 2 mM in an in vitro assay. | Measured result | assay duration not disclosed |
- Who took part
- Human studies: 22 women in the seven-day split-face study and 18 women in the 28-day study
- How it was evaluated
- In vitro glutamate-release assay; seven-day randomized split-face placebo comparison; and 28-day uncontrolled instrumental roughness study
- Statistical context
- The ingredient’s maker reports wrinkle-volume and wrinkle-length changes by day 7 and wrinkle-roughness change by day 28 in its ingredient studies.
See the full finding: Acetyl Hexapeptide-8 — split-face wrinkle studies · Open the source document (PDF)