Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies

Anagen density, telogen density, and anagen-to-telogen ratio

15% favorable anagen-density delta, 52% favorable telogen-density delta, and 79-point anagen-to-telogen-ratio delta

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports a 15% favorable anagen-density delta, 52% favorable telogen-density delta, and 79-point between-group anagen-to-telogen-ratio delta after four months in a randomized 29-person leave-on scalp study using 5% material nightly.

When it was measured

four months

Anagen density, telogen density, and anagen-to-telogen ratio

mean anagen density 9% higher, mean telogen density 42% lower, and anagen-to-telogen ratio 88% higher

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports mean anagen density 9% higher, mean telogen density 42% lower, and anagen-to-telogen ratio 88% higher at day 90 in a 23-person baseline-controlled rinse-off scalp study using 1.5% material in shampoo and conditioner every two days.

When it was measured

day 90

Specified Cutibacterium acnes ratios

specified scalp-microbiome ratios 36% and 62% lower

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports the two specified Cutibacterium acnes scalp-microbiome ratios 36% and 62% lower at day 90 in 21 people using the rinse-off regimen.

When it was measured

day 90

Lash density

up to 27% lash-density improvement with a 93% responder rate

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports up to 27% lash-density improvement with a 93% responder rate at week 8 in a 17-woman split-eye study of a 2.5% material gel versus opposite-eye placebo, used morning and evening.

When it was measured

week 8

New-lash count

45.5% more new lashes on the active side

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports 45.5% more new lashes on the active side at week 8 while the placebo side recorded no new lashes in the same 17-woman split-eye study.

When it was measured

week 8

Lash length

lash length increased by up to 0.70 mm

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports lash length increased by up to 0.70 mm at week 4 in the same 17-woman split-eye study and describes the active-side improvement as three times placebo at week 4 and five times placebo at week 8.

When it was measured

week 4; week 8

Follicle elongation

follicle elongation 58%, 51%, and 87% higher than untreated follicles

For the full Butylene Glycol, Water, Dextran, Acetyl Tetrapeptide-3, and Trifolium Pratense (Clover) Flower Extract material, Clariant reports follicle elongation 58%, 51%, and 87% higher than untreated follicles at days 4, 7, and 11 in an ex vivo assay of 22 treated and 34 untreated follicles from one donor using 1% material.

When it was measured

day 4; day 7; day 11

Follicle elongation

47% greater elongation than untreated follicles

For exact Acetyl Tetrapeptide-3, Clariant reports 47% greater elongation than untreated follicles at day 7 in an ex vivo assay of 15 peptide-treated, 27 minoxidil-reference, and 27 untreated follicles; its stated reference comparison belongs only to that assay.

When it was measured

day 7

Acetyl Tetrapeptide-3 with Clover and Dextran — hair and lash studies

For fuller-looking lash care, Acetyl Tetrapeptide-3 has been studied with Trifolium Pratense (Clover) Flower Extract and Dextran. UnderSense® places that combination beside Biotinoyl Tripeptide-1 and conditioning Jojoba Esters in its buildable lash primer.