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clinical finding

Acetyl Hexapeptide-8 — split-face wrinkle studies

in the study

Manufacturer studies of Acetyl Hexapeptide-8

what it showed

Lipotec/Lubrizol reports reduced wrinkle volume and length after seven days, reduced roughness after 28 days, and an in vitro glutamate-release result.

You will find Acetyl Hexapeptide-8 in Translucent Loose Powder.

Translucent Loose Powder creates a soft-focus setting finish. Explore the manufacturer’s wrinkle research on its Acetyl Hexapeptide-8 ingredient below.

updated 2026-09-19 · clinical finding

Complete measurements and study notes

4 details
How it was evaluated
In vitro glutamate-release assay; seven-day randomized split-face placebo comparison; and 28-day uncontrolled instrumental roughness study
Who took part
Human studies: 22 women in the seven-day split-face study and 18 women in the 28-day study
Statistical context
Lipotec/Lubrizol reports wrinkle-volume and wrinkle-length changes by day 7 and wrinkle-roughness change by day 28 in its ingredient studies.
Information checked
2026-09-12

Measured results · day 7

Wrinkle volume and length

wrinkle volume 20.6% lower and wrinkle length 15.9% lower

For Acetyl Hexapeptide-8, Lipotec/Lubrizol reports 20.6% lower wrinkle volume and 15.9% lower wrinkle length at day 7 in a randomized split-face placebo study of 22 women using a leave-on cream with 2% supplier solution twice daily.

When it was measured
day 7

Measured results · day 28

Wrinkle roughness

wrinkle roughness 20.4% lower

For Acetyl Hexapeptide-8, Lipotec/Lubrizol reports wrinkle roughness 20.4% lower at day 28 in an uncontrolled instrumental study of 18 women using a leave-on cream with 5% supplier solution twice daily.

When it was measured
day 28

Measured results · assay duration not disclosed

Glutamate release

up to 32% lower glutamate release

For Acetyl Hexapeptide-8, Lipotec/Lubrizol reports up to 32% lower glutamate release at 2 mM in an in vitro assay.

When it was measured
assay duration not disclosed

Measured results

Acetyl Hexapeptide-8 — split-face wrinkle studies

Acetyl Hexapeptide-8 has been studied for wrinkle volume, length and surface roughness. You will also find this peptide in Translucent Loose Powder, the soft-focus setting step.