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clinical finding

Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study

in the study

Manufacturer studies of Dipeptide Diaminobutyroyl Benzylamide Diacetate

what it showed

dsm-firmenich reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7; day-28 self-assessment separately included 83% average confidence agreement among 75 users.

You will find this exact peptide in NeoTight® Rejuvenating Anti-Wrinkle Serum.

In NeoTight® Rejuvenating Anti-Wrinkle Serum, this peptide contributes care for softer-looking expression lines, smoother-looking skin, and less visible shine.

updated 2026-09-23 · clinical finding

Complete measurements and study notes

5 details
How it was evaluated
In vitro gene-expression and biochemical assays; randomized 28-day parallel-group facial study; and active-cohort self-assessment
Who took part
Human study: 150 women ages 40–64 across three skin-tone groups; active self-assessment subset: 75 participants
Statistical context
The manufacturer reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7.
Information checked
2026-09-14

Measured results · day 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles

Forehead wrinkles, mouth-frown lines, upper-lip vertical lines, and forehead gloss

statistically significant improvement in selected wrinkle and gloss endpoints

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, dsm-firmenich reports statistically significant improvement in forehead wrinkles at day 28 and in mouth-frown lines, upper-lip vertical lines, and forehead gloss at day 7 in a 150-woman placebo-controlled facial study across three skin-tone groups using 4% material twice daily.

When it was measured
day 7 for mouth-frown lines, upper-lip vertical lines, and forehead gloss; day 28 for forehead wrinkles

Measured results · day 28

Smoothness, shine, beauty, and confidence

smoother, less shiny, and more beautiful-looking skin

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, dsm-firmenich reports day-28 active-cohort agreement for smoother, less shiny, and more beautiful-looking skin across the three skin-tone groups, plus 83% average confidence agreement among 75 users.

What was measured
visible smoothness, shine, beauty, and confidence
When it was measured
day 28

Measured results · 24 hours

PLOD3 gene expression

up to 3.5-fold PLOD3 gene-expression induction

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, dsm-firmenich reports up to 3.5-fold PLOD3 gene-expression induction after 24 hours in fibroblasts from a 63-year-old donor exposed to the exact peptide; this is an in vitro mechanism endpoint.

When it was measured
24 hours

Measured results · assay time not disclosed

DPP4 inhibition

dose-dependent DPP4 inhibition

For Dipeptide Diaminobutyroyl Benzylamide Diacetate, dsm-firmenich reports dose-dependent DPP4 inhibition from 0.8 to 100 ppm in a cell-free biochemical assay.

When it was measured
assay time not disclosed

Measured results

Dipeptide Diaminobutyroyl Benzylamide Diacetate — expression-line study

NeoTight® Rejuvenating Anti-Wrinkle Serum contains Dipeptide Diaminobutyroyl Benzylamide Diacetate, a synthetic peptide studied for expression-line appearance and reduced forehead shine. Beside it are Porphyridium Cruentum Extract and the Methylglucoside Phosphate and Copper Lysinate/Prolinate combination.